Yongshuo Ma
Email: yongshuo (at) mit (dot) edu

Yongshuo was born in Baoding, Hebei, China. He received his B.S. degree in Hebei Agricultural University in 2010, and M.S. degree in Nanjing Agricultural University in 2013. Since then, Yongshuo moved to Chinese Academy of Agricultural Sciences and got his Ph.D. degree in 2017. In his PhD, he mainly worked in the area of biosynthesis, regulation and transportation of natural products, including triterpenoids and alkaloid. In 2018, he joined the Metabolic Engineering Laboratory at MIT as a postdoc fellow.

Yongshuo’s research interests focus on the natural products biosynthesis and metabolic engineering, and construction of yeast chassis, especially isoprenoids.


Yongshuo Ma, Nian Liu, Per Greisen, Jingbo Li, Kangjian Qiao, Sanwen Huang, Gregory Stephanopoulos. Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica. Nature Communications, 2022, 13, 572.

Yongshuo Ma, Jingbo Li, Sanwen Huang, Gregory Stephanopoulos. Targeting pathway expression to subcellular organelles improves astaxanthin synthesis in Yarrowia lipolytica. Metabolic Engineering, 2021, 68, 152-161.

Jingbo Li, Yongshuo Ma, Nian Liu, Bekir E. Eser, Zheng Guo, Peter Ruhdal Jensen, Gregory Stephanopoulos. Synthesis of high-titer alka (e) nes in Yarrowia lipolytica is enabled by a discovered mechanism. Nature Communications, 2020, 11(1), 1-13.

Yang Zhong, Xiaofeng Xue, Zhiqiang Liu, Yongshuo Ma, et al. Developmentally regulated detoxification of bitter triterpenoid in cucumber by an UDP-glucosyltransferase, Molecular Plant, 2017, 10, 1000-1003.

Xiubin Liu, Yisong Liu, Peng Huang, Yongshuo Ma, et al. The genome of the medicinal plant Macleaya cordata provides new insights into benzylisoquinoline alkaloids metabolism, Molecular Plant, 2017, 10, 975-989.

Yongshuo Ma, Yuan Zhou, Sergey Ovchinnikov, et al. New insights into substrate folding preference of plant OSCs. Science Bulletin, 2016, 1-6.

Yuan Zhou, Yongshuo Ma, Jianguo Zeng, et al. Convergence and divergence of cucurbitacin biosynthesis and regulation in Cucurbitaceae, Nature Plants, 2016, 10.1038.

Yi Shang, Yongshuo Ma, Yuan Zhou, et al. Biosynthesis, regulation, and domestication of bitterness in cucumber, Science, 2014, 346 (6213): 1084-1088.